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GamaMabs Pharma sees two peer-reviewed articles published in Oncotarget, detailing the anti-tumor activity of GM102/3C23K

GamaMabs Pharma sees two peer-reviewed articles published in Oncotarget, detailing the anti-tumor activity of GM102/3C23K
First in class anti-AMHRII monoclonal antibody is currently completing early clinical phases in ovarian cancer

 

Paris and Toulouse, France, December 4, 2017 – GamaMabs Pharma, a biotechnology company developing optimized therapeutic antibodies targeting AMHR2 for the treatment of cancer, today announces that two peer-reviewed articles have been published in the prestigious journal, Oncotarget, elaborating on the anti-tumor activity of GamaMabs’ lead compound GM102/3C23K for ovarian cancer. The studies were performed by GamaMabs’ partners, including the Institut de Recherche en Cancérologie de Montpellier, Inserm, Institut Curie and the Institut Gustave Roussy.

GM102/3C23K is a first-in-class monoclonal antibody (mAb) targeting the anti-Müllerian human receptor II (AMHR2/MISR2) which is expressed in a large proportion of gynecological cancers. Having a high affinity towards AMHR2, GM102 displays tumor cell killing properties through the enhanced activation of immune system cells, thanks to its EMABling® glyco-engineering technology. Based on the studies’ positive results a phase Ia/Ib trial with GM102 was launched in July 2016, with initial results expected early 2018.

Both published articles drew favorable conclusions regarding GamaMabs’ GM102/3C23K candidate in pre-clinical models, describing how the compound displays an original antitumor mode of action through the activation of tumor-associated macrophages, which predominantly infiltrate the ovarian cancers. Interestingly, it has been shown that activation of those macrophages by GM102/3C23K triggers high tumor cell killing by phagocytosis followed by unlocking adaptive immune system resulting in anti-tumoral T cell proliferation.

The articles are available at:

  • P Estupina et al – The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells (https://doi.org/10.18632/oncotarget.15715)
  • H Bougherara et al – The humanized anti-human AMHRII mAb 3C23K exerts an anti-tumor activity against human ovarian cancer through tumor-associated macrophages (https://doi.org/10.18632/oncotarget.21556)

“We are absolutely delighted by the conclusions of the two articles, confirming the potential of our mAb,” said Jean-François Prost, VP R&D at GamaMabs. “Following the positive articles published in such a prestigious journal, we are looking forward to sharing the first results of our ongoing in-man Phase Ia/Ib study.”

Ovarian cancer is the fifth most frequent cause of cancer death in women, with almost 60,000 deaths every year in Europe and the United States. (Source: Globocan 2012/WHO)

About GamaMabs Pharma

GamaMabs Pharma, a French immuno-oncology biotechnology company, is a leader in the development of optimized antibodies targeting AMHR2 for the treatment of cancer. Gamamabs’ first-in-class proprietary therapeutic monoclonal antibodies promise to have a broad commercial potential in cancer. GamaMabs Pharma’s lead project is the first-inclass monoclonal antibody (mAb) GM102. This antibody, which targets the anti-Müllerian human receptor II (AMHR2/MISR2), entered a first clinical trial in gynecological cancers in H1 2016. Initial results are expected early 2018. The company develops low-fucose EMABling® antibodies (license granted by LFB) with increased tumor cell killing properties through a breakthrough activation of immune system cells. GamaMabs also has a licensing agreement with MedImmune (USA) to develop an Antibody Drug Conjugate targeting cancer.
www.gamamabs.com

 

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The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells, Pauline Estupina et al., Oncotarget February 2017

Oncotarget journal published an article on GamaMabs’12G4 antibody (3C23K precursor).

Pauline Estupina, Alexandre Fontayne, Jean-Marc Barret, Nathalie Kersual, Olivier Dubreuil, Marion Le Blay, Alexandre Pichard, Marta Jarlier, Martine Pugnière, Maëva Chauvin, Thierry Chardès, Jean-Pierre Pouget, Emmanuel Deshayes, Alexis Rossignol, Toufik Abache, Christophe de Romeuf, Aurélie Terrier, Lucie Verhaeghe, Christine Gaucher, Jean-François Prost, André Pèlegrin, Isabelle Navarro-Teulon, (2017) The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells, Oncotarget

AMH_2017_Estupina_Oncotarget

The human Müllerian inhibiting substance type II receptor as immunotherapy target for ovarian cancer, Nathalie Kersual et al., mAbs October 2014

mAbs journal published an article on GamaMabs’12G4 antibody (3C23K precursor).

Nathalie Kersual, Véronique Garambois, Thierry Chardès, Jean-Pierre Pouget, Imed Salhi, Caroline Bascoul-Mollevi, Frédéric Bibeau, Muriel Busson, Henri Vié, Béatrice Clémenceau, Christian K Behrens, Pauline Estupina, André Pèlegrin & Isabelle Navarro-Teulon (2014) The human Müllerian inhibiting substance type II receptor as immunotherapy target for ovarian cancer, mAbs, 6:5, 1314-1326

http://dx.doi.org/10.4161/mabs.29316